Society for Translational Oncology


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Targeting SWI/SNF-Hippo Axis in Squamous Cancers

Squamous cell carcinoma (SCC) remains among the most treatment-refractory of human cancers, reflecting in part a limited understanding of the key pathways and mechanisms that drive this disease. The p53-related transcription factor p63 is a central tumor maintenance factor subject to overexpression and/or genomic amplification in majority of SCCs. Loss-of-function mutations in SWI/SNF chromatin remodeling subunit genes are observed in many cancers, but an oncogenic role for SWI/SNF is not well established. We have identified ACTL6A, subunit of SWI/SNF chromatin remodeling, as frequently co-amplified and highly expressed together with p63 in head and neck, and lung squamous cell carcinoma (HNSCC & LUSC).

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Srinivas Vinod Saladi, PhD

Massachusetts Eye and Ear Infirmary, MGH, HMS, Broad Institute

STO gratefully acknowledges educational grants in partial support of this activity from:
Agios Pharmaceuticals
Celgene Corporation
Novartis Pharmaceuticals Corp.
Pfizer Inc.