Society for Translational Oncology


Highlights from STO's educational activities, including content associated with the Society and its journal The Oncologist. RSS Feed URL

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Targeting Cell Death Pathways with Precision Using Functional Assays

Anthony Letai, MD, PhD,
Dana-Farber Cancer Institute 

Video Overview:
Lecture Slides

The mitochondrial pathway of apoptosis is probably the mechanism of death in the majority of cases of response of tumors to chemotherapy. For many years, my laboratory has used a tool, BH3 profiling, to measure how close a cell is to the threshold of commitment to apoptosis. Our work suggests that how primed a cell is for apoptosis is a very important determinant for response to chemotherapy. In fact, it is probably the most important factor in determining sensitivity to conventional chemotherapy regimens. 

These lectures are designed to meet the educational needs of physicians and scientists in academic and practice settings who wish to advance their knowledge of the research into new treatments and improve their competence in the care of patients with cancer.